Highly Chemoselective Synthesis of Purino[3,2-c]oxazoles via the Asymmetric Dearomative [3 + 2] Cycloaddition of Purines with Donor-Acceptor Oxiranes was written by Zhang, Meng-Cheng;Wang, Dong-Chao;Wang, Hai-Ting;Qu, Gui-Rong;Guo, Hai-Ming. And the article was included in Organic Letters in 2022.COA of Formula: C9H6N2O2 This article mentions the following:
A Ni(II)/bisoxazoline-catalyzed asym. dearomative [3 + 2] cycloaddition of substituted purines with donor-acceptor oxiranes was developed. This reaction, which proceeds via highly chemoselective C-C bond cleavage of the oxiranes, accesses chiral purino[3,2-c]oxazole compounds (up to 99% ee after enrichment via crystallization). The electronic effects of the purine ring determine the reactivity of the substrate. The general applicability of this method was illustrated by gram-scale synthesis, the diverse transformations of the product, and the promising biol. activities of selected derivatives In the experiment, the researchers used many compounds, for example, 5-Nitroisoquinoline (cas: 607-32-9COA of Formula: C9H6N2O2).
5-Nitroisoquinoline (cas: 607-32-9) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.COA of Formula: C9H6N2O2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem