Mechanism of fasudil hydrochloride postconditioning in protecting rats against myocardial ischemia/reperfusion injury was written by Jiang, Zhi-hui;Feng, Guang-zhi;Qian, Zhi-yong;Xu, Shu-dong. And the article was included in Zhonghua Laonian Xin Nao Xueguanbing Zazhi in 2013.COA of Formula: C14H18ClN3O2S This article mentions the following:
The mechanism of fasudil hydrochloride postconditioning in protecting rats against myocardial ischemia/reperfusion (I/R) injury was studied. Thirty SD rats were randomly divided into sham operation group, I/R group, ischemic postconditioning group, fasudil hydrochloride group and fasudil hydrochloride + YZ94002 group (6 in each group). The rats were sacrificed 180 min after reperfusion. Expressions of Bcl-2, Bax, caspase 3, Akt and P-Akt in myocardial tissue were detected by Western blot. The Bcl-2 expression level was significantly higher whereas the Bax and caspase 3 expression levels were significantly lower in ischemic postconditioning group and fasudil hydrochloride group than in I/R group (P<0.05). The Bcl-2 expression level was significantly lower whereas the Bax and caspase 3 expression levels were significantly higher in fasudil hydrochloride + LY294002 group than in fasudil hydrochloride group (P<0.05). The Akt expression level was significantly higher in fasudil hydrochloride group than in I/R group and fasudil hydrochloride+LYZ94002 group (P<0.05). Fasudil hydrochloride postconditioning can protect rats against myocardial I/R injury possibly by activating the PI3K-Akt pathway. In the experiment, the researchers used many compounds, for example, 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7COA of Formula: C14H18ClN3O2S).
5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. COA of Formula: C14H18ClN3O2S
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem