Substrate scope in the direct imine acylation of ortho-substituted benzoic acid derivatives: the total synthesis (±)-cavidine was written by Kitsiou, Christiana;Unsworth, William P.;Coulthard, Graeme;Taylor, Richard J. K.. And the article was included in Tetrahedron in 2014.HPLC of Formula: 52250-50-7 This article mentions the following:
The direct imine acylation (DIA) and subsequent cyclization of a range of imines with ortho-substituted benzoic acid derivatives is described. Variation in the coupling reagents, imine and benzoic acid were all examined The DIA procedure was also applied in the total synthesis of (±)-cavidine (I). In the experiment, the researchers used many compounds, for example, 1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7HPLC of Formula: 52250-50-7).
1-Phenyl-3,4-dihydroisoquinoline (cas: 52250-50-7) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.HPLC of Formula: 52250-50-7
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem