Microwave-accelerated fluorodenitrations and nitrodehalogenations: expeditious routes to labeled PET ligands and fluoropharmaceuticals was written by La Beaume, Paul;Placzek, Michael;Daniels, Mathew;Kendrick, Ian;Ng, Patrick;McNeel, Melissa;Afroze, Roushan;Alexander, Abigail;Thomas, Rhiannon;Kallmerten, Amy E.;Jones, Graham B.. And the article was included in Tetrahedron Letters in 2010.Electric Literature of C9H6N2O2 This article mentions the following:
Methods for the expeditious fluorination of arenes have been investigated, using readily available fluoride sources. An optimized procedure for microwave-accelerated fluorodenitration has been developed, giving good to excellent yields in less than 10 min, rendering it practical for use in the preparation of F18 labeled ligands for PET imaging. Application of the method in the synthesis of CNS agents is demonstrated, and a practical method for the preparation of substrates is also presented. In the experiment, the researchers used many compounds, for example, 5-Nitroisoquinoline (cas: 607-32-9Electric Literature of C9H6N2O2).
5-Nitroisoquinoline (cas: 607-32-9) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Electric Literature of C9H6N2O2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem