Properties and Exciting Facts About 4-Bromoisoquinoline

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Palladium-catalysed amination of halopyridines on a KF-alumina surface

Palladium-catalysed C-N hetero cross-coupling reactions between bromopyridines and amines (both primary and secondary) can be efficiently performed on a KF-alumina (basic) surface, thus negating the use of strong bases such as sodium tert-butoxide. The reaction conditions are optimised with reference to catalytic systems, solvents and the surface.

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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem