82827-09-6, 6-Bromoisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Under nitrogen atmosphere, 22 mg of 60% sodium hydride was added at 0C to 3 ml solution of dimethylformamide with 100 mg of 6-bromo-2H-isoquinoline-1-one, and the mixture was stirred for 30 min. 0.04 ml of ethyl iodide was added at 0C, and the mixture was stirred at room temperature for 3 hours. Cold water was added to the reaction solution, extracted with chloroform. Chloroform layer was washed with saturated saline solution, and dried with anhydrous sodium sulfate. After distilling out the solvents under reduced pressure, the residues were separated and purified by thin-layer chromatography (hexane/ethyl acetate=3/1) to obtain 30 mg of the above compound as a white solid. 1HNMR(400MHz,CDCl3.)delta.:1.38(3H,t,J=7.4Hz), 4.04(2H,q,J=7.2Hz), 6.41(1H,d,J=7.2Hz), 7.10(1H,d,J=7.6Hz), 7.56(1H,dd,J=1.8,8.6Hz), 7.67(1H,d,J=2.0Hz), 8.28(1H,d,J=8.4Hz) ESI-MS Found:m/z 253.9[M+H]+
The synthetic route of 82827-09-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1726585; (2006); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem