With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52986-70-6,6-Methoxyisoquinoline,as a common compound, the synthetic route is as follows.
52986-70-6, General procedure: A flame-dried and nitrogen flushed 50 mL Schlenk flask, equipped with a magnetic stirringbar, was charged with the appropriate isoquinoline 7a-c (prepared according to lit. [1,2])(2.00 mmol) in dry THF (10 mL). TMPMgClLiCl (1.0 M in THF/toluene; 3.00 mL, 3.00 mmol)was added to this solution dropwise over 2 min. The reaction mixture was stirred at roomtemperature for 4 h. After cooling to 0 C, a solution of iodine (0.761 g, 3.00 mmol) in dryTHF (3 mL) was added dropwise to the reaction mixture. The cooling bath was removed andthe mixture was stirred at room temperature for 1 h. Then the mixture was quenched withsatd. aqueous NH4Cl solution (4 mL) and satd. aqueous Na2S2O3 solution (4 mL). Afterextraction with dichloromethane (3 ¡Á 20 mL), the combined organic layers were dried withNa2SO4, and concentrated under reduced pressure. The residue was purified by flashcolumn chromatography (ethyl acetate/dichloromethane = 1:5).
52986-70-6 6-Methoxyisoquinoline 11040978, aisoquinoline compound, is more and more widely used in various.
Reference£º
Article; Melzer, Benedikt C.; Bracher, Franz; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 1564 – 1571;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem