1532-97-4, Name is 4-Bromoisoquinoline, belongs to isoquinoline compound, is a common compound. COA of Formula: C9H6BrNIn an article, once mentioned the new application about 1532-97-4.
Heck arylations of pent-4-enoates or allylmalonate using a palladium/tetraphosphine catalyst
The Heck reaction of aryl halides with functionalised alk-1-enes should be a powerful method for the synthesis of functionalised (E)-1-arylalk-1-ene derivatives. The major problem of this reaction is the palladium-catalysed migration of the carbon-carbon double bond along the alkyl chain when there are no substituents on the C3 carbon of the alk-1-enes. We observed that for the arylation of ethyl pent-4-enoate, ethyl 2-methylpent-4-enoate or dimethyl allylmalonate this migration could be partially or completely controlled using appropriate reaction conditions. The ramification on the alkyl chain and the substituents on the aryl halide have also an important influence on this migration. Moreover, the cis,cis,cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane/1/2[PdCl(C3H5)]2 system catalyses this reaction with a wide range of aryl bromides using very high ratio substrate/catalyst in good yields.
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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem