With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20232-39-7,6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride,as a common compound, the synthetic route is as follows.
General procedure: A solution of dihydroisoquinoline hydrochloride salt (9.3 g, 40.9 mmol) and methyl vinyl ketone 7b (6.1g, 49.1 mmol) in absolute EtOH (41 mL) was stirred at 90 ¡ãC for 48 h. After the reaction mixture was cooled to rt, the solvent and the excess of reagent were removed in vacuo. The residue was chromatographed (SiO2, 20percent EtOAc/Hexanes to 50percent EtOAc/Hex). Product 8b was obtained as pale yellow solid (2.2 g, 17percent yield).
20232-39-7, As the paragraph descriping shows that 20232-39-7 is playing an increasingly important role.
Reference£º
Article; Zheng, Pinguan; Lieberman, Brian P.; Choi, Seok Rye; Plo?essl, Karl; Kung, Hank F.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 11; (2011); p. 3435 – 3438;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem