1532-97-4, 4-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 1654-[5-(4-Dimethylamino-piperidin-1-yl)-3H-imidazo[4,5-b]pyridine-2-carbonyl]-2- isoquinolin-4-yl-benzonitrileSynthetic scheme Step i4-Cyano-3-isoquinolin-4-yl-benzoic acid methyl esterThe mixture of 4-cyano-3-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester (100 mg, 0.348 mmole), 4-bromo-isoquinoline (80 mg, 0.383 mmole), Pd2(dba)3 (31.9 mg, 0.035 mmole), Sphos (28.6 mg, 0.070 mmole), 2 molar K3PO4 aqueous (0.4 ml, 0.8 mmole) and dioxane (5 ml) was degassed and heated to 1200C for 40 minutes in microwave. Reaction solution was diluted with water and extracted with EtOAc. EtOAc layer was concentrated. Residue was purified by using silica gel chromatography, eluting with EtOAc/ heptane to afford 4-cyano-3-isoquinolin-4-yl-benzoic acid methyl ester (60 mg, 60 percent). 1 H NMR (400MHz, CD2CI2) delta 3.88 (s, 3H), 7.45 (d, J=8.03 Hz, 1 H), 7.65 (m, 2H), 7.90 (m, 1 H), 8.06 (d, J=8.53 Hz, 1 H), 8.15 (m, 2H), 8.42 (s, 1 H), 9.29 (s, 1 H). HR-MS m/z 289.0979 [M+1]., 1532-97-4
The synthetic route of 1532-97-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; ASTEX THERAPEUTICS LIMITED; HOWARD, Steven; MORTENSON, Paul Neil; HISCOCK, Steven Douglas; WOOLFORD, Alison Jo-Anne; WOODHEAD, Andrew James; CHESSARI, Gianni; O’REILLY, Marc; CONGREVE, Miles Stuart; DAGOSTIN, Claudio; CHO, Young Shin; YANG, Fan; CHEN, Christine Hiu-Tung; BRAIN, Christopher Thomas; LAGU, Bharat; WANG, Yaping; KIM, Sunkyu; GRIALDES, John; LUZZIO, Michael Joseph; PEREZ, Lawrence Blas; WO2010/125402; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem