423146-25-2, Name is 6-(6-Morpholino-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanoic acid, belongs to isoquinoline compound, is a common compound. Product Details of 423146-25-2In an article, once mentioned the new application about 423146-25-2.
Highly fluorescent and HDAC6 selective scriptaid analogues
Fluorescent scriptaid analogues with excellent HDAC6 selectivity (HDAC1/6 > 500) and potency (HDAC6 IC50 < 5 nM) have been synthesised and evaluated. The highly fluorescent nature of the compounds (up to PhiF = 0.83 in DMSO and 0.38 in aqueous buffer) makes them ideally suited for cellular imaging and visualisation of their cytoplasmic localisation was readily accomplished. Whole organism imaging in zebrafish confirmed both the vascular localisation of the new inhibitors and the impact of HDAC6 inhibition on in vivo development.
Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 423146-25-2
Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H4103N – PubChem