With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55270-27-4,4-Bromoisoquinolin-1-amine,as a common compound, the synthetic route is as follows.,55270-27-4
General procedure: To a solution of CuI (0.1 eq), Pd(PPh3)2Cl2 (0.05 eq) and compound7 (1 eq) in MeCN (5 mL) were added ArBr (Ar a, b, c, e, f, g,h, k, l) or ArI (Ar q, r, s, t) (3 eq) and trimethylamine (1.5 eq). Thereaction mixture was flushed with argon and sealed in a pressuretube. The reaction mixture was stirred at 80 C for 3-4 h. The reactionmixture was extracted with EtOAc, washed with water andbrine and concentrated in vacuo. The product was dissolved inMeOH (15 mL) at 60 C for 1 h. The organic solvent was removed invacuum. The crude mixture was purified by column chromatographyon silica gel to give 8a, 8b, 8c, 8e, 8f, 8g, 8h, 8k, 8l, 8q, 8r, 8s,8t.To a solution of ArI (Ar = n, p) (3 eq) in MeCN (5 mL) was addedtrimethylamine (5 mL). The mixture was stirred at room temperaturefor 1 h, after which time CuI (0.1 eq), Pd(PPh3)2Cl2 (0.05 eq)and compound 7 (1 eq) were added. The reaction mixture wasflushed with argon and sealed in a pressure tube. The reactionmixture was stirred at 50 C for 24 h. The reaction mixture wasextracted with EtOAc, washed with water and brine and concentratedin vacuum. The product was then dissolved in MeOH (15 mL)at 60 C for 1 h. The organic solvent was removed in vacuo. Thecrude mixturewas purified by column chromatography on silica gelto give 8n and 8p.
As the paragraph descriping shows that 55270-27-4 is playing an increasingly important role.
Reference£º
Article; Ma, Cong-Xuan; Lv, Wei; Li, Ya-Xin; Fan, Bing-Zhi; Han, Xu; Kong, Fan-Sheng; Tian, Jing-Chao; Cushman, Mark; Liang, Jian-Hua; European Journal of Medicinal Chemistry; vol. 169; (2019); p. 1 – 20;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem