With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21902-40-9,1,3-Dichloro-5-methylisoquinoline,as a common compound, the synthetic route is as follows.
N-Bromosuccinimide (0.77 mL, 9.05 mmol) and AIBN (248 mg, 1.51 mmol) were added portionwise to a suspension of 1,3-dichloro-5-methylisoquinoline (1.60 g, 7.54 mmol) in degassed EtOAc (20 mL) at reflux under a nitrogen atmosphere. The resulting solution was stirred at reflux for 16 hours. The mixture was concentrated to provide an orange solid. The crude product was purified by flash silica chromatography with 40% DCM in heptane as eluent. Pure fractions were evaporated to dryness to afford 5-(bromomethyl)-1,3-dichloroisoquinoline (1.64 g, 75%) as a colourless solid., 21902-40-9
21902-40-9 1,3-Dichloro-5-methylisoquinoline 21518478, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Article; Holmes, Jane L.; Almeida, Lynsie; Barlaam, Bernard; Croft, Rosemary A.; Dishington, Allan P.; Gingipalli, Laksmaiah; Hassall, Lorraine A.; Hawkins, Janet L.; Ioannidis, Stephanos; Johannes, Jeffrey W.; McGuire, Thomas M.; Moore, Jane E.; Patel, Anil; Pike, Kurt G.; Pontz, Timothy; Wu, Xiaoyun; Wang, Tao; Zhang, Hai-Jun; Zheng, Xiaolan; Synthesis; vol. 48; 8; (2016); p. 1226 – 1234;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem