1532-97-4, Name is 4-Bromoisoquinoline, belongs to isoquinoline compound, is a common compound. Application In Synthesis of 4-BromoisoquinolineIn an article, once mentioned the new application about 1532-97-4.
2-Pyridones, 2-quinolinones, and 1-isoquinolinones are critical building blocks in medicinal chemistry. These N-heterocycles, however, remain a challenge to synthesize by current methods. A mild, general, and efficient approach for the synthesis of these hydroxyl N-heteroarenes was developed by employing bromotripyrrolidinophosphonium hexafluorophosphate (PyBroP) as an activating agent and sodium acetate/water as the base/nucleophile combination. The reaction mechanism, especially the dual function of sodium acetate as the base and nucleophile, has been proposed on the basis of results from isotopic labeling experiments.
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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H3404N – PubChem