58142-99-7,58142-99-7, 5-Iodoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Tert-butyl (R)-2-methyl-5-carbonylpiperazine-1-carboxylate (1.1 g, 5.14 mmol),5-Iodoisoquinoline(1.64 g, 6.43 mmol), cuprous iodide (356 mg, 1.87 mmol), potassium phosphate (3.34 g, 9.87 mmol), ethylenediamine (3 mL), 4A molecular sieves (10 g) dissolved in 1,4- Dioxane (50 mL) reacts overnight at 120C in a nitrogen atmosphere.The reaction was monitored by LCMS, followed by filtration with water. The filtrate was extracted with dichloromethane three times. The organic phases were combined, dried, and the solvent was removed by rotary evaporation. Column chromatography gave 4-isoquinoline-(R)-2-methyl-5-carbonyl. Tert-butyl piperazine-1-carboxylate (537 mg, yield: 31%).
58142-99-7 5-Iodoisoquinoline 11391181, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Liu Gang; Wu Yongyong; Yu Hua; Wang Kunjian; Li Xiaoyong; Sun Ling; Wang Runjiang; Chen Qiangqiang; Yang Long; Song Hongmei; Zeng Hong; Zhang Hong; Ye Qijun; Wang Lichun; Wang Jingyi; (98 pag.)CN107540659; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem