With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.
To a solution of isoquinoline-5-sulfonyl chloride hydrochloride (930 mg) in THF (20 ml) were added DIPEA (2.2 eq.) and (S-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester (1 eq.). The reaction mixture was stirred at room temperature overnight. The solvent was evaporated and the residue was taken in DCM. The DCM layer was washed with 1 N sodium carbonate and then, with brine. The organic layer was evaporated and the residue was purified by chromatography on C-18 (water/CH3CN 100/0 to 50/50) to afford the intermediate methyl ester as a white powder (66 % yield).
105627-79-0, The synthetic route of 105627-79-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; DEVGEN N.V.; WO2008/49919; (2008); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem