With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6624-49-3,Isoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.
6624-49-3, General procedure: To a solution of carboxylic acid (3 equiv) in DMF was added N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (EDCI, 3 equiv), hydroxybenzotriazole (HOBt, 3 equiv), molecular sieves, and Et3N (5 equiv) on an ice-water bath under N2 protection. After 15min, a solution of 17 (1 equiv) in DMF was added. The reaction mixture was stirred overnight at room temperature. The mixture was filtered through celite and the filtrate was concentrated in vacuum to remove DMF. The residue was dissolved in CH3OH and added potassium carbonate (2 equiv). The resulting mixture was stirred overnight at room temperature. After concentration, the residue was partitioned between water and CH2Cl2.The water layer was extracted with CH2Cl2, the combined extract was washed with brine,and dried over Na2SO4. After concentration, the residue was purified by silica gel column with a CH2Cl2/CH3OH (50:1) (1percent NH3H2O) solvent system as eluent to give the target product.
As the paragraph descriping shows that 6624-49-3 is playing an increasingly important role.
Reference£º
Article; Zhang, Yan; Elbegdorj, Orgil; Yuan, Yunyun; Beletskaya, Irina O.; Selley, Dana E.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 13; (2013); p. 3719 – 3722;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem