With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22246-04-4,7-Methoxy-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.
0.2 mol sodium hydroxide was dissolved in 200ml N,N-dimethyl formamide, then the oil (0.1 mol) prepared instep (2) was added, The reaction was stirred in ice bath for 0.5 hour, and then iodomethane (0.15 mol) was slowlyadded dropwise. After the addition was completed, the reaction was conducted at room temperature for 10 hours.After the reaction was completed, the reaction solution was poured into 1 L ice water to terminate the reaction.Extraction with ethyl acetate was conducted. The organic layer was washed with saturated saline solution, driedover anhydrous magnesium sulfate. The solvent was removed by rotary evaporateion to give 17.8 g of brown solid.Yield: 93%.MS (ESI) m/z 191.1 ([M+H]+), 22246-04-4
The synthetic route of 22246-04-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NHWA Pharma Corporation; CHEN, Yin; DOU, Fei; QIU, Yinli; YU, Minquan; ZHANG, Guisen; (42 pag.)EP3381915; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem