With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215453-51-3,7-Bromo-1-chloroisoquinoline,as a common compound, the synthetic route is as follows.
215453-51-3, To a solution of compound 1.5 (3 g, 12.4 mmol, 1 eq) in NMP (30 mL) was addedNH.HzO (30 mL). The mixture was stirred 150C for 15 hours. The reaction mixture wasquenched by addition H20 100 mL at 25 C, and then extracted with EtOAC (100 mL x 3). The combined organic layers were washed with saturated brines (15 mL x 1), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a crude product. The residue was purified by column chromatography (Si02, Petroleum ether/Ethylacetate=1:1). Compound 1.4 (2.0 g, 9 mmol, 72.42% yield) was obtained as a brown oil. LCMS (ESI): m/z: [M + H] calcd for C9H7N2Br:223; found 223; RT=1.049 mm.
As the paragraph descriping shows that 215453-51-3 is playing an increasingly important role.
Reference£º
Patent; CORTEXYME, INC.; LYNCH, Casey C.; KONRADI, Andrei; GALEMMO, JR., Robert A.; (218 pag.)WO2018/209132; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem