With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63927-23-1,5-Bromo-8-nitroisoquinoline,as a common compound, the synthetic route is as follows.
63927-23-1, EXAMPLE 26 5-Bromo-2-ethyl-1,2,3,4-tetrahydro-8-nitroisoquinoline A solution of 5-bromo-8-nitroisoquinoline (1 g, 3.95 mmol) in 20 mL THF was cooled to 0 C. and treated sequentially with sodium borohydride (0.75 g, 19.83 mmol) followed by the slow addition of acetic acid (20 mL). The reaction mixture was allowed to warm to room temperature, and an additional 2 equiv. of sodium borohydride was added. After quenching with water and treatment with sodium hydroxide solution to make basic, the reaction mixture was extracted with ethyl acetate. The organic residue was chromatographed on silica gel (25% ethyl acetate in hexane) to give the N-ethyl-5-bromo-8-nitrotetrahydroisoquinoline (0.8 g, 70% yield).
As the paragraph descriping shows that 63927-23-1 is playing an increasingly important role.
Reference£º
Patent; BIGGE, CHRISTOPHER F.; MALONE, THOMAS C.; WATJEN, FRANK; US2003/114422; (2003); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem