With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23687-25-4,Isoquinolin-4-amine,as a common compound, the synthetic route is as follows.,23687-25-4
To a stirring solution of 4-aminoisoquinoline (1.4 g, 10.0 mmol) in 5 N aqueous hydrochloric acid (12 mE) at 00 C. was added a solution of sodium nitrite (NaNO2, 0.069 g, 10.0 mmol) in deionized water (1 mE), while maintaining the internal temperature below 00 C. The reaction mixture was stirred at 00 C. for 30 mm and a solution of tin(II) chloride dihydrate (SnC12.2H20, 5.6 g, 25.0 mmol) dissolved in concentrated hydrochloric acid (5 mE) was added dropwise. The mixture was stirred at room temperature for 2 h and the solution was adjusted to pH -12-14 with 20% aqueous sodium hydroxide. The mixture was extracted with 2:1 CHC13/iPrOH. The organic layer was dried (Na2SO4), filtered, and concentrated in vacuo. The resulting crude product was purified by flash chromatography (Si02, 50% ethyl acetate in hexanes) to give the desired compound (0.84 g, 5.3 mmol, 53%)
As the paragraph descriping shows that 23687-25-4 is playing an increasingly important role.
Reference£º
Patent; ChemoCentryx, Inc.; Cappel, Markus; (83 pag.)US2018/9797; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem