1532-97-4, Name is 4-Bromoisoquinoline, belongs to isoquinoline compound, is a common compound. Application In Synthesis of 4-BromoisoquinolineIn an article, once mentioned the new application about 1532-97-4.
The first examples of acetone mono-alpha-arylation at room temperature are described, enabled by use of a [Pd(cinnamyl)Cl]2/JosiPhos catalyst system. (Hetero)aryl chloride, bromide, and iodide electrophiles featuring or lacking ortho-substitution, and comprising a range of functionalities (e.g., alkoxy, cyano, fluoro, trifluoromethyl, or alkenyl) and heteroaryl motifs (e.g., pyrrole, pyridine, isoquinoline, quinoline, quinaldine, (benzo)thiophene, benzothiazole, or benzodioxole) were successfully accommodated. Proof-of-principle experiments confirm that other (hetero)aryl methyl ketones can also be employed in such room temperature mono-alpha-arylations. The established substrate scope is the most extensive reported to date for acetone mono-alpha-arylation under any conditions, and more generally represents the first room temperature ketone mono-alpha-arylations employing a structurally diverse set of (hetero)aryl chlorides. Chill out: The first examples of acetone mono-alpha-arylation at room temperature are described. The substrate scope is the most extensive reported to date for acetone mono-alpha-arylation under any conditions, and represents the first room temperature ketone mono-alpha-arylations employing a diverse set of (hetero)aryl chlorides.
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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H3259N – PubChem