With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1532-97-4,4-Bromoisoquinoline,as a common compound, the synthetic route is as follows.
General procedure: One mmol each of the isoquinolines (1a?c), phenacyl bromide (2a?f)/ 2-bromoacetonitrile (2g), and benzoyl isothiocyanate (3) were taken in a 100 ml RB flask.Then water (50 ml), CTAB (4 mmol) and Amberlite resin 420 (1 mmol) were added andthe mixture was stirred continuously for 1.5 h at room temperature. After completion of the reaction (monitored by TLC), the solid was filtered off, washed thoroughly withwater (until free from CTAB), Then the solid was dried, and dissolved in chloroform andagain filtered to separate base (Amberlite resin 420) from solution. The compound furtherpurified by recrystallization from chloroform to yield the thiazolo[2,3-a]isoquinolin-4-ium derivatives (4a?r).
1532-97-4, As the paragraph descriping shows that 1532-97-4 is playing an increasingly important role.
Reference£º
Article; Maity, Arindam; Chakraborty, Debanjana; Hazra, Abhijit; Bharitkar, Yogesh P.; Kundu, Sandip; Maulik, Prakas R.; Mondal, Nirup B.; Tetrahedron Letters; vol. 55; 19; (2014); p. 3059 – 3063;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem