552331-06-3,552331-06-3, 6-Bromo-3-chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Synthesis of Compound 2e: A solution of 6-bromo-3-chloro-isoquinoline (Frontier Scientific, Logan, Utah USA) (8.0 g, 33 mmol) and tributyl-(1-ethoxy-vinyl)-stannane (14.88 g, 14 mL, 41.2 mmol) in toluene (100 mL) was degassed with nitrogen for 30 min. Bis(triphenylphosphine)palladium(ll) dichloride (1.16 g, 1 .65 mmol, 5 mol%) was added and the reaction mixture was heated at 60 C for 20 h. The reaction mixture was cooled to room temperature, the mixture was filtered and the filtrate was evaporated. The residue was purified by silica gel chromatography using a gradient of /’so-hexanes/ethyl acetate 20:1 to 10:1 to afford the title compound (7.1 g, 92%) as a pale yellow solid.
As the paragraph descriping shows that 552331-06-3 is playing an increasingly important role.
Reference£º
Patent; GILEAD SCIENCES, INC.; SELCIA LIMITED; STEADMAN, Victoria Alexandra; POULLENNEC, Karine G.; LAZARIDES, Linos; ACIRO, Caroline; DEAN, David Kenneth; KEATS, Andrew John; SIEGEL, Dustin Scott; SCHRIER, Adam James; MACKMAN, Richard; JANSA, Petr; WO2013/185093; (2013); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem