So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Boyle, Benjamin T.; Hilton, Michael C.; McNally, Andrew researched the compound: Diphenyl-2-pyridylphosphine( cas:37943-90-1 ).Formula: C17H14NP.They published the article 《Non-symmetrical bis-azine biaryls from chloroazines: a strategy using phosphorus ligand-coupling》 about this compound( cas:37943-90-1 ) in ChemRxiv. Keywords: hetero biaryl synthesis phosphorus ligand coupling. We’ll tell you more about this compound (cas:37943-90-1).
Distinct approaches to synthesize bis-azine biaryls are in demand as these compounds have multiple applications in the chem. sciences and are challenging targets for metal-catalyzed cross-coupling reactions. Most approaches focus on developing new reagents as the formal nucleophilic coupling partner that can function in metal-catalyzed processes. We present an alternative approach using pyridine and diazine phosphines as nucleophilic partners and chloroazines where the heterobiaryl bond is formed via a tandem SNAr-phosphorus ligand-coupling sequence. The heteroaryl phosphines are prepared from chloroazines and are bench stable solids. Using this strategy, a range of bis-azine biaryls can be formed from abundant chloroazines that would be challenging using traditional approaches and a one-pot cross-electrophile coupling of two chloroazines is feasible. Thus, e.g., treatment of 2-(diphenylphosphinyl)-6-methylpyridine with 3,4-dichloropyridine, NaOTf, HCl and dioxane followed by HCl in dioxanes, H2O and TFE afforded I (81%).
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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem