The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-(5-Bromothiophen-2-yl)pyridine, is researched, Molecular C9H6BrNS, CAS is 123784-07-6, about β-Strand Mimicry: Exploring Oligothienylpyridine Foldamers, the main research direction is beta strand mimicry oligothienylpyridine foldamer exploration B3LYP.Quality Control of 2-(5-Bromothiophen-2-yl)pyridine.
Protein-protein interactions (PPIs) are involved in many cellular processes; consequently, the discovery of small mols. as modulators of PPIs has become an important challenge in medicinal chem. Structural mimetics of α-helixes, β-turns or β-strands could maintain or restore biol. functions and should possess biol. activity. At this time, the most challenging classes of PPIs are those mediated by β-sheet interactions, which are implicated in a number of diseases. Only a few β-strand mimics have been published to date. This study presents an evaluation of oligothienylpyridyl scaffolds in view of their ability for β-strand mimicry. In this study, theor. ring twist angle predictions for these scaffolds have been validated by X-ray diffraction and mol. dynamics simulations with NMR constraints. Careful choice of substituent and heavy-atom positions in the foldamer units opens the way to produce reasonably coplanar compounds mimicking β-strand side-chain distribution.
After consulting a lot of data, we found that this compound(123784-07-6)Quality Control of 2-(5-Bromothiophen-2-yl)pyridine can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem