In a broader sense, the term isoquinoline is used to make reference to isoquinoline derivatives. 1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. The isoquinoline ring in these natural compound derives from the aromatic amino acid tyrosine. Related Products of 1532-97-4.
Tang, Shuang-Qi;Schmitt, Martine;Bihel, Frederic research published 《 POxAP Precatalysts and the Negishi Cross-Coupling Reaction》, the research content is summarized as follows. Recently developed for the Fukuyama reaction, post-oxidative addition precatalysts (POxAPs) were also very efficient in catalyzing Negishi cross-coupling reactions between organohalides and organozinc reagents. Using very low catalyst loadings, POxAPs showed similar catalytic activities to those of classical precatalysts such as XPhos Pd G4 or PEPPSI-IPr, with turnover numbers of up to 93,000. POxAPs were easily prepared, and stable to air and moisture, tolerate a wide range of functional groups in the Negishi cross-coupling reaction and contribute advantageously to the arsenal of organic chemists in terms of Pd precatalysts.
Related Products of 1532-97-4, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.
4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., 1532-97-4.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem