In a broader sense, the term isoquinoline is used to make reference to isoquinoline derivatives. 1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. The isoquinoline ring in these natural compound derives from the aromatic amino acid tyrosine. Application of C9H6BrN.
Theeramunkong, Sewan;Thiengsusuk, Artitiya;Vajragupta, Opa;Muhamad, Phunuch research published 《 Synthesis, characterization and antimalarial activity of isoquinoline derivatives》, the research content is summarized as follows. Abstract: This paper presents synthesis of novel decorated isoquinolines that can be used as antimalarial agents. Two series of compounds, isoquinoline Ph and isoquinoline triazole derivatives, were synthesized via the Suzuki-Miyaura and Sharpless-Fokin reactions resp. The final compounds were investigated for their antimalarial activity in cell-based experiments In the series of isoquinoline Ph derivatives, compound 6 exhibited interesting antiplasmodial activity against chloroquine resistant (K1) and chloroquine sensitive (3D7) strains of P. Falciparum with IC50 1.91 ± 0.21μM and 2.31 ± 0.33μM, resp. In the series of isoquinoline-triazole derivatives, compound 15 was the most active against resistant (K1) and sensitive (3D7) strains of P. falciparum with IC50 4.55 ± 0.10μM and 36.91 ± 2.83μM, resp. The resp. resistance indexes of compounds 6 and 15 against K1 and 3D7 were 0.83 and 0.12. Compound 15 was promisingly effective against the resistant strain. The results of this study provided useful contributions for further lead discovery and lead modification of modern rational drug design.
1532-97-4, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.
4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., Application of C9H6BrN
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem