Tian, Wan-Fa team published research on ChemistrySelect in 2020 | 1532-97-4

Application of C9H6BrN, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.

4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., 1532-97-4.

Isoquinoline is a heterocyclic aromatic organic compound. 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. It is a structural isomer of quinoline. Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. Application of C9H6BrN.

Tian, Wan-Fa;He, Ke-Han;Li, Na;Fen;Liu;Mai, Xi;Feng, Li-Hua;He, Yong-Qin research published 《 Transition-Metal-Free Coupling Reactions: PPh3-Promoted Sonogashira-Type Cross-Couplings of Heteroaryl Halides with Terminal Alkynes》, the research content is summarized as follows. Synthesis phenylethynyl heteroaryl I [Ar1 = 2-pyridyl, 6-Me-3-pyridyl, 3-quinolyl, etc.; Ar2 = Ph 2-FC6H4, 4-MeOC6H4, etc.] via Sonogashira-type cross-coupling reaction of heteroaryl halides with terminal alkynes under mild transition-metal-free conditions using PPh3 and Cs2CO3/NEt3 was reported, a wide range of functional groups was tolerated under optimized conditions. Furthermore, the protocol would be extended to the Suzuki-type cross-coupling of heteroaryl halides with phenylboronic acid, to gave the Ph heteroaryl II [Ar3 = 3-pyridyl, 5-pyrimidinyl, 3-quinolyl, etc.] in good to excellent yields. A test reaction on gram scale delivered the product in reasonably high yield and thus had the potential of promising applications in drug discovery and functional materials.

Application of C9H6BrN, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.

4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., 1532-97-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem