Zeng, Jia; Lytle, Anna K.; Gage, David; Johnson, Sean J.; Zhan, Jixun published the artcile< Specific chlorination of isoquinolines by a fungal flavin-dependent halogenase>, Category: isoquinoline, the main research area is halogenase Rdc1 Pochonia isoquinoline specific chlorination; chloroisoquinoline biosynthesis halogenase Rdc1 Pochonia.
Rdc2 of Pochonia chlamydosporia is the 1st flavin-dependent halogenase identified from fungi. Based on the reported structure of the bacterial halogenase CmlS, the authors built a homol. model for Rdc2. The model suggested an open substrate binding site that was capable of binding the natural substrate, monocillin II, and possibly other mols. such as 4-hydroxyisoquinoline (I) and 6-hydroxyisoquinoline (II). In vitro and in vivo halogenation experiments confirmed that I and II could be halogenated at the position ortho to the OH group, leading to the synthesis of the chlorinated isoquinolines, 3-chloro-4-hydroxyisoquinoline and 5-chloro-6-hydroxyisoquinoline, resp., which further expanded the spectrum of identified substrates of Rdc2. This work revealed that Rdc2 is a useful biocatalyst for the synthesis of various halogenated compounds
Bioorganic & Medicinal Chemistry Letters published new progress about Pochonia chlamydosporia. 3336-49-0 belongs to class isoquinoline, and the molecular formula is C9H7NO, Category: isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem