Wu, Wei; Wang, Yan; Guo, Jing; Cai, Liu; Chen, Yuan; Huang, Yanmin; Peng, Yungui published the artcile< Asymmetric acyl-Mannich reaction of isoquinolines with α-(diazomethyl)phosphonate and diazoacetate catalyzed by chiral Bronsted acids>, SDS of cas: 90806-58-9, the main research area is diazo isoquinoline phosphonate acetate asym synthesis; isoquinoline enantioselective acyl Mannich diazomethyl phosphonate diazoacetate.
An efficient asym. acyl-Mannich reaction of isoquinolines with di-Et pyrocarbonate and α-(diazomethyl)phosphonate or diazoacetate has been developed using chiral spiro phosphoric acids as catalysts. This reaction allowed the construction of a series of chiral α-diazo-β-isoquinoline phosphonates and acetates I [R1 = H, 5-Cl, 7-MeO, 4-Ph, etc.; X = (MeO)2P(O), MeO2C, EtO2C, i-PrO2C, t-BuO2C] bearing a tertiary stereocenter at the C1 position with up to 98% yield and 99% ee.
Chemical Communications (Cambridge, United Kingdom) published new progress about Bronsted acids Role: CAT (Catalyst Use), USES (Uses). 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, SDS of cas: 90806-58-9.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem