Ahmed, Wasim; Huang, Zi-Hao; Cui, Zi-Ning; Tang, Ri-Yuan published the artcile< Design and synthesis of unique thiazoloisoquinolinium thiolates and derivatives>, Electric Literature of 90806-58-9, the main research area is thiazoloisoquinolinium thiolate preparation; isoquinoline ethylpropionate cycloaddition; alkylthio thiazoloisoquinolinium iodide preparation; alkyl halide thiazoloisoquinolinium thiolate nucleophilic substitution; epithiometheno thiazinoisoquinoline carboxylate preparation; terminal alkyne thiazoloisoquinolinium thiolate cycloaddition.
The synthesis of unique mesoionic thiazoloisoquinolinium thiolates stabilized by aromatization and 1,3-dipolarization. Herein, compounds were synthesized via the three component [2+2+1] cycloaddition reaction of isoquinolines with Et propionate and elemental sulfur in the absence of any metal catalyst and additives. Importantly, thiazoloisoquinolinium thiolates were transformed to thioether-containing thiazoloisoquinolinium halides. A selective [4+2] cycloaddition were also used to form S-bridged fused tetracyclic compounds with a thiothiamide ring unit and two quaternary carbon centers. Compound I showed good bioactivity against the chlorophyll of duckweed (Lemna minor) with inhibition rate of 51.5μg/mL.
Chinese Chemical Letters published new progress about [2+2+1] Cycloaddition reaction. 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Electric Literature of 90806-58-9.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem