Arundel-Suto, Carla M.; Scavone, Sylvia V.; Turner, William R.; Suto, Mark J.; Sebolt-Leopold, Judith S. published an article in Radiation Research. The title of the article was 《Effects of PD 128763, a new potent inhibitor of poly(ADP-ribose) polymerase, on x-ray-induced cellular recovery processes in Chinese hamster V79 cells》.Reference of 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one The author mentioned the following in the article:
The modifying effects of PD 128763 (3,4-dihydro-5-methyl-1(2H)-isoquinolinone) (I), a potent inhibitor of poly(ADP-ribose)polymerase, on radiation-induced cell killing were examined in Chinese hamster V79 cells. I has an IC50 value against the purified enzyme 50-fold lower than 3-aminobenzamide (3-AB), a widely used specific inhibitor of the enzyme. Exposure of exponentially growing cells to a noncytotoxic concentration (0.5 mM) of I for 2 h immediately following x-irradiation increased their radiation sensitivity, modifying both the shoulder and the slope of the survival curve. When recovery from sublethal damage and potentially lethal damage was examined in exponential and plateau-phase cells, resp., postirradiation incubation with 0.5 mM I not only to inhibited both these processes fully, but also enhanced further the level of radiation-induced cell killing. This is in contrast to the slight effect seen with the less potent inhibitor, 3-AB. The mechanism of radiosensitization by I is related to the potent inhibition of poly(ADP-ribose) polymerase by this compound After reading the article, we found that the author used 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one(cas: 129075-56-5Reference of 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one)
5-Methyl-3,4-dihydroisoquinolin-1(2H)-one(cas: 129075-56-5) belongs to isoquinoline.Reference of 5-Methyl-3,4-dihydroisoquinolin-1(2H)-one Isoquinoline is a structural isomer of quinoline, and quinoline derivatives are fused ring compounds of pyridine and benzene rings, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem