With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84468-15-5,Isoquinoline-5-sulfonyl chloride,as a common compound, the synthetic route is as follows.
To a solution of compound 33b, 4-Methyl-2-(5-piperidin-3-yl-4′-trifluoromethyl-biphenyl-3-yl)-pentanoic acid ethyl ester (48.0 mg, 0.106mmol) in anhydrous dichloromethane (4 ml) was added isoquinoline -5-sulfonyl chloride (42.1 mg, 0.16 mmol) and DIEA (37.0 mul, 0.21 mmol). The reaction stirred at room temperature over 72 hours, was diluted with dichloromethane and washed with sat. NaHCO3, and brine, dried and filtered. Purification by silica gel chromatography (Isco) gave the desired product, (60.0 mg, 88%). Calcd for C35H37F3N2O4S (M+H) 638.74, Found 639.3.
84468-15-5, The synthetic route of 84468-15-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; HO, Chih Yung; US2009/105275; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem