Xiong, Qian; Dong, Shunxi; Chen, Yushuang; Liu, Xiaohua; Feng, Xiaoming published the artcile< Asymmetric synthesis of tetrazole and dihydroisoquinoline derivatives by isocyanide-based multicomponent reactions>, Formula: C10H9NO, the main research area is alkylidene malonate diastereoselective enantioselective annulation isoquinoline isocyanide; imino dihydro pyrroloisoquinoline dicarboxylate enantioselective diastereoselective preparation; isocyanide trimethylsilyl azide alkylidene malonate enantioselective heterocyclization; tetrazole diester enantioselective preparation.
Herein, several isocyanide-based multicomponent reactions based on enantioselective addition of simple isocyanides to C=C bonds were realized in the presence of a chiral Mg(II)-N,N’-dioxide catalyst. Three- or four-component reactions of an isocyanide, TMSN3, and an (alkylidene)malonate could be precisely controlled by modulating reaction conditions to afford two types of enantioenriched tetrazole derivatives in moderate to high yields. Possible catalytic cycles via a key zwitterionic intermediate, and the vital roles of H2O or excess ligand are provided based on control experiments Moreover, taking advantage of this zwitterionic intermediate as a 1,3-dipole, an enantioselective dearomative [3+2] annulation reaction of nonactivated isoquinolines is achieved, furnishing chiral dihydropyrrolo[2,1-a]isoquinolines in good to excellent results.
Nature Communications published new progress about Diastereoselective synthesis. 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Formula: C10H9NO.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem