Analyzing the synthesis route of 622867-52-1

The synthetic route of 622867-52-1 has been constantly updated, and we look forward to future research findings.

622867-52-1, tert-Butyl 6-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,622867-52-1

Add activated manganese(IV) oxide (2.85 g, 32.77 mmol) to a solution of 6-hydroxymethyl-3 ,4-dihydro- 1H-isoquinoline-2-carboxylic acid tert-butyl ester (863.00mg, 3.28 mmol) in dichloromethane (50.00 mL) at room temperature and stir at thattemperature for 16 hours. Filter over a pad of CELITE and wash the CELITE pad with dichioromethane. Concentrate the filtrate under reduced pressure to afford the title compound (740 mg, 2.83 mmol). MS (m/z): 206 (M+1-tBu).

The synthetic route of 622867-52-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; BURKHOLDER, Timothy Paul; DEL PRADO, Miriam Filadelfa; FERNANDEZ, Maria Carmen; HEINZ II, Lawrence Joseph; PRIETO, Lourdes; ZHAO, Genshi; WO2015/54060; (2015); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem