On June 18, 1982, Kashdan, David S.; Schwartz, John A.; Rapoport, Henry published an article.Category: isoquinoline The title of the article was Synthesis of 1,2,3,4-tetrahydroisoquinolines. And the article contained the following:
Several aspects of 1,2,3,4-tetrahydroisoquinoline synthesis were examined An improved synthesis of 2-(m-methoxyphenyl)ethylamine (I) is reported. m-Anisaldehyde was treated with KCN and EtO2CCl to yield O-(ethoxycarbonyl)-3-methoxymandelonitrile. Hydrogenation gave I in 87% yield overall. Some observations were made regarding the reduction of 3,4-dihydroisoquinolines derived from the Bischler-Napieralski reaction. Amides II (R = R1 = MeO; R = H, R1 = OCH2Ph) were cyclized with POCl3 followed by reduction to the corresponding tetrahydroisoquinolines III, which were contaminated with 4% of IV (R = R1 = MeO) and 3% of IV (R = H, R1 = OCH2Ph), resp. Both IV (R = R1 = OMe) and IV (R = H, R1 = OCH2Ph) were independently synthesized by routes with general applicability to 8-alkoxy-1,2,3,4-tetrahydroisoquinolines. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Category: isoquinoline
The Article related to tetrahydroisoquinoline, hydroisoquinoline tetra, isoquinoline tetrahydro, phenethylbenzeneacetamide bischler napieralski cyclization, acetamide phenethylbenzene cyclization and other aspects.Category: isoquinoline
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem