On November 5, 2015, Wu, Lingyun; Yao, Yuanshan; Chen, Zhaoguo; Chen, Shuhui published a patent.SDS of cas: 58142-46-4 The title of the patent was Preparation of isoquinolinesulfonyl derivatives as Rho kinase inhibitors. And the patent contained the following:
The invention relates to isoquinolinesulfonyl derivatives (e.g., I) and their pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical preparations comprising them, and their use as Rho kinase inhibitors. For instance, the invention compound I was prepared and gave a ROCK kinase inhibition IC50 value of <0.1μM. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).SDS of cas: 58142-46-4
The Article related to isoquinolinesulfonyl preparation rho kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.SDS of cas: 58142-46-4
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem