On September 1, 2020, Yu, Xiyong; Lan, Huiyao; Hu, Wenhui; Yang, Zhongjin; Wu, Nannan published a patent.Recommanded Product: 1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one The title of the patent was Azaindoles and their application as antitumor drugs. And the patent contained the following:
The invention provides azaindoles and its application, which can effectively inhibit the phosphorylation of SMAD3, and has good antitumor activity in the tumor model induced by LCC in rats. The invention provides azaindole or its pharmaceutically acceptable salt or stereoisomer or prodrug mol. as shown in formula I, wherein D is selected from C and N; and R2 does not exist when D is N; A and B are independently selected from N and CR3; R1 is selected from H, C1-C6 alkyl, C6-C10 aryl, C3-C8 cycloalkyl, halogen, CN; R2 selected from: H, C1-C6 alkyl; each R3 is independently selected from H, C1-C6 alkyl, halogen, CN; R4 is selected from carbonyl compounds; R5, R5a, R5b = H, halogen, CN, C1-C6 alkyl, C3-C8 cycloalkyl. For example, compound II was prepared in a multi-step synthesis. The title compound can be used as a pharmaceutical composition for the prevention and/or treatment of cancer. The experimental process involved the reaction of 1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one(cas: 1009104-85-1).Recommanded Product: 1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one
The Article related to azaindole anticancer agent elimination reaction amidation substitution, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem