On April 23, 2019, Shen, Jianhua; Leng, Ying; Chen, Tingting; Wang, Kai; Ning, Mengmeng published a patent.SDS of cas: 74904-29-3 The title of the patent was Preparation of amide compounds as GPR40 agonists. And the patent contained the following:
The title amide compound is shown in formula I, wherein, A is 5-7-membered heteroaryl or 6-10-membered aryl; M is O, S or N-alkyl; R1 is H or halogen; R2 is hydroxypropyl, cyclopropyl or propynyl; R3 is H, alkyl, alkoxy or halogen; R4 and R5 are independently selected from H, indanyl, alkyl, 5-7-membered heterocyclic group, etc. The inventive amide compound is capable of regulating GPR40 activity, and can be applied in treating GPR40 activity-related diseases, such as diabetes and metabolic syndrome. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).SDS of cas: 74904-29-3
The Article related to amide preparation gpr40 agonist, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.SDS of cas: 74904-29-3
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem