On April 30, 2021, Wang, Dao-Cai; Yan, Ting-Ting; Chen, Bin; Liu, Feng; Liu, Xiao-Peng; Xie, Yong-Mei published an article.Name: 1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one The title of the article was SIS3, a good candidate for the reverse of type 2 diabetes mellitus in mice. And the article contained the following:
TGF-β signaling plays an extremely important role in the occurrence and development of type 2 diabetes mellitus (T2DM), and the blockade of TGF-b/Smad3 pathway protests against the high-fat diet-induced obesity and diabetes. As a specific small mol. inhibitor of Smad3 protein, the biol. activities of compound SIS3 were evaluated by high-fat diet-induced T2DM model mice. In vivo results indicated that SIS3 can not only significantly reduce the body weight, fat mass, and fasting blood glucose in high-fat diet-induced T2DM model mice, but also improve insulin sensitivity and oral glucose tolerance of high-fat diet-induced T2DM model mice after the injection of SIS3 with 5 mg/kg for 45 days. The experimental process involved the reaction of 1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one(cas: 1009104-85-1).Name: 1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one
The Article related to compound sis diabetes mellitus mouse, sis3, smad3 inhibitor, treatment, type 2 diabetes mellitus, Pharmacology: Effects Of Agents For Treating Metabolic and Endocrine Disorders and other aspects.Name: 1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem