On October 31, 1978, Hamada, Yoshiki; Sugiura, Michiharu; Hirota, Minoru published an article.Related Products of 58142-46-4 The title of the article was Studies on nitrogen-containing heterocyclic compounds. XXXIII. Syntheses of 3-alkoxyisoquinolines and 7-,8-substituted-1,6-naphthyridines from isoquinoline and 1,6-naphthyridine. And the article contained the following:
1,3-Dialkoxy-4-bromo-2-cyano-1,2,3,4-tetrahydroisoquinolines are obtained quant. by the addition of BrCN to isoquinoline dissolved in the corresponding alc., followed by application of Br and saturated sodium carbonate solution These products are a mixture of stereoisomers with the H atoms in 3- and 4-positions in cis (main) and trans configuration. Dehydrobromination of the cis-type compounds with KCN easily gives 3-alkoxyisoquinolines. Hydrolysis with HCl affords 4-bromoisoquinoline from cis-type compounds and 4-chloroisoqinoline from trans-type compounds 4-Bromo-5-nitroisoquinoline was obtained from 5-nitroisoquinoline by the application of the above reaction but 3-methoxy-5-nitroisoquinoline could not be obtained. Application of this reaction to 1,6-naphthyridine easily gave 8-bromo-1,6-naphthyridine and 7-methoxy-1,6-naphthyridine. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Related Products of 58142-46-4
The Article related to isoquinoline alkoxy, naphthyridine methoxy, cyanoisoquinoline alkoxy, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Related Products of 58142-46-4
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem