On February 28, 2021, Aseem, Sayed Obaidullah; Jalan-Sakrikar, Nidhi; Chi, Cheng; Navarro-Corcuera, Amaia; De Assuncao, Thiago M.; Hamdan, Feda H.; Chowdhury, Shiraj; Banales, Jesus M.; Johnsen, Steven A.; Shah, Vijay H.; Huebert, Robert C. published an article.Computed Properties of 1009104-85-1 The title of the article was Epigenomic Evaluation of Cholangiocyte Transforming Growth Factor-β Signaling Identifies a Selective Role for Histone 3 Lysine 9 Acetylation in Biliary Fibrosis. And the article contained the following:
Transforming growth factor β (TGFβ) upregulates cholangiocyte-derived signals that activate myofibroblasts and promote fibrosis. Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) was used to investigate changes in chromatin accessibility. TGFβ stimulation caused widespread changes in histone 3 lysine 27 acetylation (H3K27ac), and was associated with global TGFβ-mediated transcription. In contrast, H3K9ac was gained in a smaller group of chromatin sites and was associated with fibrosis pathways. These pathways included overexpression of hepatic stellate cell (HSC) activators such as fibronectin 1 (FN1) and SERPINE1. The promoters of these genes showed H3K9ac enrichment following TGFβ. Of the acetyltransferases responsible for H3K9ac, cholangiocytes predominantly express Lysine Acetyltransferases 2A (KAT2A). Small interfering RNA knockdown of KAT2A or H3K9ac inhibition prevented the TGFβ-mediated increase in FN1 and SERPINE1. SMAD3 ChIP-seq and ATAC-seq suggested that TGFβ-mediated H3K9ac occurs through SMAD signaling, which was confirmed using colocalization and genetic knockdown studies. Pharmacol. inhibition or cholangiocyte-selective deletion of Kat2a was protective in mouse models of biliary fibrosis. Cholangiocyte expression of HSC-activating signals occurs through SMAD-dependent, KAT2A-mediated, H3K9ac, and can be targeted to prevent biliary fibrosis. The experimental process involved the reaction of 1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one(cas: 1009104-85-1).Computed Properties of 1009104-85-1
The Article related to biliary fibrosis cholangiocyte transforming growth factor histone h3 acetylation, epigenetics, fn, pai1, Mammalian Pathological Biochemistry: Digestive Tract Diseases and other aspects.Computed Properties of 1009104-85-1
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem