Nishimura, Rodolfo H. V. published the artcileSelective Functionalization of Benzo-Fused N-Heterocycles by Using In Situ Trapping Metalations, Category: isoquinoline, the main research area is benzo fused heterocycle preparation regioselective.
Some benzo-fused N-heterocycles, e.g., I were prepared by regioselective metalation of quinoline, isoquinoline, quinoxaline and quinazoline with LiTMP in the presence of zinc chloride. Applying this strategy to synthesize an analog of the antitumor verubulin illustrated its relevance for medicinal chem. Computational calculations of the pKa values of the aromatic hydrogens helped to rationalize substrate reactivity and metalation regioselectivity by the complex-induced proximity effect concept.
ChemistrySelect published new progress about Metalation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem