Li, Yigao published the artcileFe(III)-Catalyzed N-Amidomethylation of Secondary and Primary Anilines with TosMIC, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is alpha amino amide preparation; isocyanide aniline amidomethylation multicomponent iron catalyst.
A Fe(III)-catalyzed N-amidomethylation of secondary and primary anilines with p-toluenesulfonylmethyl isocyanide (TosMIC) in water was described. TosMIC played dual roles as the source of methylene as well as an amidating reagent to form α-amino amides R1N(R2)CH2C(O)NHR3 [R1 = Ph, 2-MeC6H4, 4-FC6H4, etc.; R2 = H, Me, Bn, etc.; R3 = t-Bu, 4-MeC6H4SO2CH2, 4-ClC6H4SO2CH2] in this multicomponent reaction. The combination of TosMIC and other isocyanides was also investigated to give the desired products in acceptable yields. The current protocol features used of iron catalyst and nontoxic media, broad substrate scope, mild conditions and operational simplicity.
Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem