White, Nicholas A. published the artcilePhosphoramidates as Steering Elements for Highly Selective Access to Complementary Imidazo[1,2-a]pyrimidine Isomers, Application of 4-Methoxy-N-methylaniline, the main research area is imidazopyrimidine isomer preparation; phosphoryl aminoimidazole ethoxy acrylamide condensation; aminobenzimidazole diethyl chlorophosphate phosphorylation.
Selective N-phosphorylation of aminoimidazoles results in a key steering element that controls isomeric selectivity in the condensation of β-ethoxy acrylamides and aminoimidazoles to furnish imidazo[1,2-a]pyrimidines is reported. Conditions that provide highly selective (99:1) phosphorylation at the endo- or exocyclic nitrogen are identified. Either the 2-amino or 4-amino isomer of the (benzo)imidazo[1,2-a]pyrimidine products could be isolated in 64-95% yield. Mass spectrometric anal. and computational studies give insight into the mechanism of this exceptionally selective transformation.
Organic Letters published new progress about Benzimidazoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (amino). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem