Tanaka, Tsukushi published the artcileChemoselective Catalytic α-Oxidation of Carboxylic Acids: Iron/Alkali Metal Cooperative Redox Active Catalysis, Related Products of isoquinoline, the main research area is tetramethyl piperidinyl oxy arylacetic acid preparation chemoselective; carboxylic acid piperidinyloxy tetramethyl enolization iron catalyst.
Chemoselective catalytic activation of carboxylic acid for a 1e- radical process is described. The α-oxidation of a variety of carboxylic acids HOC(O)CH2R (R = 4-methylphenyl, 2H-1,3-benzodioxol-5-yl, thiophen-3-yl, etc.), which preferentially undergo undesired decarboxylation under radical conditions, proceeded efficiently under the optimized conditions. Chemoselective enolization of carboxylic acid was also achieved even in the presence of more acidic carbonyls. Extensive mechanistic studies revealed that the cooperative actions of iron species and alkali metal ions derived from 4 Å mol. sieves substantially facilitated the enolization. For the first time, catalytic enolization of unprotected carboxylic acid was achieved without external addition of stoichiometric amounts of Bronsted base. The formed redox-active heterobimetallic enediolate efficiently coupled with free radical TEMPO, providing synthetically useful α-hydroxy and keto acid derivatives R3OC(O)CH(OR2)R (R2 = 2,2,6,6-tetramethylpiperidin-1-yl, 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-yl, 2,2,6,6-tetramethyl-4-(prop-2-yn-1-yloxy)piperidin-1-yl, 2,2,6,6-tetramethyl-4-(methylcarbonylamino)piperidin-1-yl; R3 = H, Me).
Journal of the American Chemical Society published new progress about Aromatic esters Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Related Products of isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem