Buckley, Aoife M. published the artcileDirhodium Carboxylate Catalysts from 2-Fenchyloxy or 2-Menthyloxy Arylacetic Acids: Enantioselective C-H Insertion, Aromatic Addition and Oxonium Ylide Formation/Rearrangement, Synthetic Route of 104-01-8, the main research area is dirhodium carboxylate preparation; arylacetic acid diazocarbonyl compound addition reaction; tetrahydrothiopyran preparation enantioselective diastereoselective; diazooxosulfone carbon hydrogen insertion rhodium catalyst; Aromatic Addition; Carbenoids; C−H Insertion; Diazo Compounds; Rhodium Catalysis.
A new class of dirhodium carboxylate catalysts I (Ar = Ph, naphthalen-2-yl, 4-bromophenyl, etc.; R = 1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl, menthyl) have been designed and synthesized from 2-fenchyloxy or 2-menthyloxy arylacetic acids ArC(OR)COOH which display excellent enantioselectivity across a range of transformations of α-diazocarbonyl compds ArC(=N2)C(O)Ot-Bu. The catalysts were successfully applied to enantioselective C-H insertion reactions of aryldiazoacetates and α-diazo-β-oxosulfones R1(CH2)4S(O)OC(=N2)C(O)R2 (R1 = Ph, octyl, 4-fluorophenyl, etc.; R2 = Me, Bn, Ph) and Me 2-((cyclohexylethyl)sulfonyl)-2-diazoacetate affording the resp. products II and Me (1R,4aS,8aR)-octahydro-1H-isothiochromene-1-carboxylate 2,2-dioxide in up to 93% ee with excellent trans diastereoselectivity in most cases. Furthermore, efficient desymmetrization in an intramol. C-H insertion was achieved. In addition, these catalysts prove highly enantioselective for intramol. aromatic addition with up to 88% ee, and Me 2-diazo-3-(2-allyloxyphenyl)-3-oxopropionate formation and rearrangement with up to 74% ee.
ChemCatChem published new progress about Diastereoselective synthesis. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem