Bora, Pranjal P. published the artcileShielding Effect of Micelle for Highly Effective and Selective Monofluorination of Indoles in Water, SDS of cas: 151-10-0, the main research area is indole fluoro bisbenzenesulfonimide water surfactant medium regioselective monofluorination; fluoroindole preparation green chem; arene fluorobenzenesulfonimide water surfactant medium regioselective monofluorination; fluoroarene preparation green chem; E-factor; fluorination; green chemistry; micelles; sustainability.
Highly selective direct monofluorination of indoles and arenes was developed through an approach that allows site-specific solubility of substrate and fluorine source in the micelle. This approach was highly selective for a broad range of substrates with excellent functional group tolerance. Differences in binding constant and solubility of indoles and arenes in the micelle allowed the fine-tuning of selectivity. Control experiments suggested a radical pathway and provided insight into the role of micelles of the environmentally benign amphiphile PS-750-M. Dynamic light scattering experiments strongly indicated the site-specific solubility of the substrate and fluorine source. The methodol. was successfully adapted to gram scale and the E-factor established from a recycle study indicated that the process was environmentally responsible and sustainable.
ChemSusChem published new progress about Fluorination, regioselective. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 151-10-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem