Wu, Xiaopeng published the artcileDecarboxylative acylation of carboxylic acids: reaction investigation and mechanistic study, HPLC of Formula: 104-01-8, the main research area is aromatic aliphatic ketone preparation photochem one pot; carboxylic acid aromatic aliphatic thioester decarboxylative acylation.
Ketones serve as one of the most critical building blocks in organic synthesis, involving numerous functional group transformations. Herein, authors report an unprecedented photoredox-nickel metallaphotoredox-catalyzed decarboxylative acylation of common aliphatic acids with readily available aromatic and aliphatic thioesters. A wide range of structurally diverse asym. aryl alkyl and dialkyl ketones have been constructed in yields of up to 98% with this strategy. The protocol has excellent reaction selectivity and functional group compatibility, representing a significant step forward in ketone synthesis. The one-pot decarboxylative acylation at the gram scale from two different carboxylic acids and the late-stage application for the synthesis of complex ketones shows its synthetic robustness. Both mechanistic experiments and d. functional theory (DFT) calculations suggest that the decarboxylative acylation reaction operates via an underdeveloped Ni(I)-Ni(II)-Ni(I)-Ni(III)-Ni(I) catalytic cycle.
CCS Chemistry published new progress about Acylation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, HPLC of Formula: 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem